Cst fam134b
WebOct 28, 2024 · In contrast, FAM134B may rather act as a tumor suppressor, since FAM134B mutations have been frequently found in colorectal adenocarcinoma, and esophageal squamous cell carcinoma [41, 43, 73]. Highly specific and rigorously validated in-house, FAM134B (E8Y9R) Rabbit Monoclonal Antibody (CST #83414) is ready to ship. ... FAM134B (family with sequence similarity 134, member B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may contribute to ...
Cst fam134b
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WebFAM134B contains a conserved LC3 interacting domain (LIR) that facilitates binding to LC3 and GABARAP family members and targets impaired ER to the autophagosome for degradation by ER-phagy (2). ... Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products ... WebApr 18, 2024 · Here we report that in cancer cells, hypoxia-induced ER stress activates ER-phagy through the ER-phagy receptor FAM134B. Upon hypoxic stress, FAM134B is included in a complex with the ER chaperone ...
WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and … WebThe protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional …
WebDec 14, 2024 · FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but … WebJun 23, 2024 · The recent identification of FGF/TFEB/FAM134B signaling event represents the first study that implicates the role of TFEB in ER-phagy and its physiological relevance during skeletal development in ...
WebJan 13, 2024 · FAM134B forms oligomers that are required for ER membrane scission and ER-phagy A. Endogenous FAM134B forms oligomers. FAM134B knockout (KO) or wild-type (WT) 293T cells were treated with 1 μM of Thapsigargin (Tg) for different time, and the cell lysates were prepared and analyzed by Western blot.
WebDec 14, 2024 · FAM134B (also called RETREG1) is a critical gene for neuronal survival. FAM134B loss-of-function mutations cause hereditary sensory and autonomic neuropathy type II, and its knockdown results in structural alterations of the cis -Golgi compartment, inducing apoptosis in some primary dorsal root ganglion neurons ( 25 ). dan frost northwestern mutualWebOct 4, 2016 · FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga Abhilash I. Chiramel, Jonathan D. Dougherty, Vinod Nair, Shelly J. Robertson, Sonja M. Best birmingham kitchen supplyWebNational Center for Biotechnology Information birmingham kitty cafeWebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, FAM134B Antibody (CST #61011) is … birmingham kings heath driving test centreWebMay 30, 2024 · FAM134B, the first ER-phagy receptor to be identified, contains a reticulon-homology domain (RHD). FAM134B targets ER … birmingham kittycafe.co.ukWebAug 24, 2024 · Several ER surface receptors, including FAM134B, reticulon 3L (RTN3L), Sec62, and CCPG1, have been shown to contain conserved LC3-interacting regions (LIRs) that can act as specific autophagy receptors to allow portions of the larger ER network to be shunted to core autophagy pathways ( Khaminets et al., 2015; Fumagalli et al., 2016; … dan frost freezerWebFAM134B overexpression also ameliorated the AE-induced ultrastructural damage in neuronal mitochondria, decrease in mitochondrial membrane potential (mMP), cytochrome c (CytC) release and caspase-3 activation, while FAM134B downregulation induced the … danf tech