WebDec 29, 2024 · Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the polycomb repressive complex 2, plays an important role in tumor development and progression by interacting with histone and non‐histone proteins. ... This study investigates the prognostic relevance of immunohistochemical EZH2 expression in head and neck squamous cell … WebMar 24, 2024 · Enhancer of zeste homolog 2 inhibitors (EZH2i) have garnered increased attention owing to their anticancer activity by targeting EZH2, a well-known cancer-promoting factor. However, some lymphomas are resistant to EZH2i, and EZH2i treatment alone is ineffective in case of EZH2-overexpressing solid tumors. The anti-cancer …
EZH2 is a negative prognostic biomarker associated with ... - PLOS
WebSep 17, 2024 · In accordance with these findings, other preclinical studies showed that the combination of EZH2 inhibitors and ICBs is highly synergistic in hepatocellular carcinoma … WebMay 20, 2009 · Methods: Expression of EZH2, Ki-67, and p53 was determined by immunohistochemical staining of tissue microarrays from specimens of 138 cases of head and neck squamous cell carcinoma. Results: High EZH2 expression was observed in 51.5%. 44.2% were positive for p53. The percentage of Ki-67 staining was significantly … blcms.org
EZH2 is associated with poor prognosis in head-and-neck …
WebSep 6, 2024 · Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide with rates of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) dramatically increasing. The overexpression of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for the trimethylation at … WebAug 5, 2024 · The antitumor activity of EZH2i alone was not effective in solid tumors overexpressing EZH2, such as ovarian cancer, head and neck cancer, and prostate cancer. Therefore, the development of novel EZH2 specific inhibitors is very important to overcome the limited clinical efficacy of pyridone inhibitors and the targeted toxicity of non-specific ... WebAug 15, 2024 · Malignant neoplasm of head, face and neck C76.1 Malignant neoplasm of thorax C76.2 Malignant neoplasm of abdomen C76.3 Malignant neoplasm of pelvis C76.40 Malignant neoplasm of unspecified upper limb C76.42 blc membership