WebApr 3, 2024 · The germinal center (GC) reaction is unique in that it incorporates clonal expansion, somatic mutagenesis, affinity-based selection, and differentiation events all in … WebJul 22, 2024 · The germinal center (GC) reaction generates high-affinity antibody–producing plasma cells and memory B cells that are pivotal for immune …
EZH2-mediated epigenetic silencing in germinal center B cells ...
WebAbstract. Somatic hypermutation of immunoglobulin variable region (IgV) genes and affinity maturation of the antibody response are the hallmarks of the germinal center (GC) … WebApr 11, 2024 · Thus, eliciting the RBD-specific B cells to the longitudinal germinal center reaction confers potent immunity to broad SARS-CoV-2 variants emerging one after another. barron banks
Cancers Free Full-Text Impact of a Faulty Germinal Center Reaction ...
WebDec 9, 2010 · EZH2 is up-regulated in normal germinal center (GC) B cells and is implicated in lymphomagenesis. To explore the transcriptional programs controlled by EZH2, ... AP1 drives B lymphocyte maturation by activating Blimp1, 29 which promotes the exit of B cells from the GC reaction and their differentiation into plasma cells. 30 Thus, ... WebDec 17, 2024 · The failure of the germinal center (GC) reaction and its checkpoints increases tumor B cell affinity for the CNS. During this faulty GC reaction, PCNSL tumor cells acquire further oncogenic alterations converging on the Toll-like receptor, B cell receptor, and NF-κB pathway. These activated pathways sustain proliferation. WebJun 13, 2014 · Perturbations of the GC reaction impair the generation of protective high-affinity antibodies and cause the development of humoral autoimmunity. Thus, parsing out the mechanisms that regulate the GC response is critical to better understand both immunity to infections and autoimmune disorders. suzuki v strom 1050 xt manual