Lcmv infection model of mice
Previous work showed that, despite being less functional than virus-specific cells generated upon an acute infection, exhausted CD8 T cells are capable of efficient in vivo killing of target cells isolated from a naive host32. To corroborate that gp33–41-pulsed target cells originating from naive mice and … Meer weergeven Previous studies showed that, compared to classical effector CD8 T cells formed in acute infection, exhausted virus-specific CD8 T cells are transcriptionally distinct and fail to exert several effector functions, such as … Meer weergeven There is extensive work showing that exhausted CD8 T cells have a dysfunctional transcriptional network compared to … Meer weergeven In order to investigate the TCR signaling in an in vivo setting, we took advantage of a transgenic mouse model, in which GFP is expressed under the control of the Nr4a1 promoter24. NUR77, encoded by Nr4a1, is triggered by … Meer weergeven The in vitro data suggested that the TCR signaling was still functional to some extent, documented by increased GFP expression after restimulation of exhausted P14-Nr4a1-GFP cells. Several hypotheses … Meer weergeven Web19 feb. 2024 · To determine if LCMV infects and replicates in the colon, we established an i.rec. infection model with this pathogen. We fasted WT mice for 16 h to limit gut content, and after bowel...
Lcmv infection model of mice
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Web7 apr. 2024 · Well-established mouse models of infection, such as LCMV and IAV, provided us with many immunological tools to interrogate the impact of T reg cells on … Web17 aug. 2024 · Mice infected with LCMV WE v54, which differed from v2.2 by a single amino acid in the viral glycoprotein, failed to generate MUP above baseline levels found …
Web29 sep. 2024 · Ever since the immune regulatory strains of lymphocytic choriomeningitis virus (LCMV), such as Clone 13, were isolated, LCMV infection of mice has served as … Web7 apr. 2024 · Well-established mouse models of infection, such as LCMV and IAV, provided us with many immunological tools to interrogate the impact of T reg cells on virus-specific T cells.
Web12 apr. 2024 · This drop is in line with CXCR3 expression changes in subsets of exhausted cells in mice chronically infected with LCMV 5 or bearing B16-OVA tumors 4 as … Web29 apr. 2024 · LCMV is a noncytolytic virus, which is widely used as a model system to study chronic infections, virus-induced immunopathology, effector responses, immune …
Web19 aug. 2024 · Many LCMV strains have been isolated from human patients and rodents, with extensive genetic and phenotypic differences . The Armstrong (Arm) strain was first …
Web1 nov. 2011 · LCMV infection of its natural reservoir host, the mouse, can vary widely depending on the age and strain of the mouse and the dose, strain and infection-route … cuyahoga county ohio marriage license recordsWebHere we examine the roles of NK cells in regulating T-cell-dependent viral persistence and immunopathology in mice infected with LCMV, an … cuyahoga county ohio medicaid officeWeb11 apr. 2024 · Like apoptotic cells, also EVs display phosphatidylserine (PS) on their outer membrane layer (23–26).Based on this marker, we previously described a sensitive and … cuyahoga county ohio housing authorityWebOne of the best-studied model systems of viral infections is that of the lymphocytic choriomeningitis virus (LCMV) in mice (Figure 1) [ 1 – 3 ]. LCMV is an RNA virus of … cuyahoga county ohio probate court searchWebIn this study, we developed a CD4 + T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of … cuyahoga county ohio property tax bill searchWebLymphocytic choriomeningitis virus (LCMV) is an arenavirus that is a natural pathogen of mice but can be transmitted to humans. Human infection with LCMV is frequently … cheaper ticket for algiersWeb7 jun. 1998 · Lymphocytic choriomeningitis virus (LCMV) infection in mice provides an example of an extraordinarily dynamic process with an extreme sensitivity of phenotype … cheaper tires nampa