Webb18 aug. 2024 · Abstract. Compound potency is a key metric that is often used to drive medicinal chemistry programs. Compound potency is also taken into account when … Biological responses to ligand concentrations typically follow a sigmoidal function. The inflection point at which the increase in response with increasing ligand concentration begins to slow is the EC50, which can be mathematically determined by derivation of the best-fit line. While relying on a graph for estimation is more convenient, this typical method yields less accurate results and less precise.
130 PROTEIN A QUALITY ATTRIBUTES - uspbpep.com
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