Trx1 has been shown to downregulate cardiac hypertrophy, the thickening of the walls of the lower heart chambers, by interactions with several different targets. Trx1 upregulates the transcriptional activity of nuclear respiratory factors 1 and 2 (NRF1 and NRF2) and stimulates the expression of peroxisome … See more Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN … See more The primary function of Thioredoxin (Trx) is the reduction of oxidized cysteine residues and the cleavage of disulfide bonds. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, … See more Thioredoxin has been shown to interact with: • ASK1, • Collagen, type I, alpha 1, See more • RuBisCO - enzyme activity regulated by thioredoxin • Peroxiredoxin - enzyme activity regulated by thioredoxin See more They are found in nearly all known organisms and are essential for life in mammals. See more Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. … See more Thioredoxin is used in skin care products as an antioxidant in conjunction with glutaredoxin and glutathione. See more WebJan 3, 2024 · In this study, we found that thioredoxin-interacting protein (Txnip), a regulator of oxidoreductase, controlled reactive oxygen species (ROS) metabolism via the nuclear …
Thioredoxin-interacting protein links oxidative stress to
WebApr 1, 2008 · In the current issue of Diabetes, Chen et al. ( 4) provide evidence that the loss of β-cell mass in response to elevated concentrations of glucose is the results of … WebMar 22, 2024 · Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein 2 (TBP-2)/vitamin D3up-regulated protein 1 (VDUP1), is an α-arrestin that can bind … omt and low back pain
Thioredoxin-Interacting Protein Is Killing My β-cells!
WebMar 3, 2024 · Thioredoxin-interacting protein (TXNIP) has emerged as an important factor in pancreatic beta cell biology, and tight regulation of TXNIP levels is necessary for beta cell survival. However, the ... WebJan 23, 2007 · Loses its reducing activity, interaction with APEX1 and transcription activation; when associated with S-35. 1 publication. Sequence: C → S: ... PTHR46115:SF1 THIOREDOXIN-LIKE PROTEIN 1 1 hit; PIRSF. PIRSF000077 Thioredoxin 1 hit; PRINTS. PR00421 THIOREDOXIN; PROSITE. View protein in PROSITE; PS00194 THIOREDOXIN_1 1 … WebOct 21, 2024 · Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and … omta music teachers association